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467 Studies using Zip13-KO mice have shown elevated levels of the cardiac fibrosis marker Col1a1 and the vascular inflammation-related gene eNOS, indicating the physiological importance of ZIP13 in maintaining cardiovascular homeostasis by resolving inflammation and stress response

Some participants in trials also reported fatigue, though this was not uniformly documented across all study arms

doi:10.1136/thx.2005.048512

GLP-1 RAs are the first weight-reduction medications that are safe and improve CV outcomes