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Assisted reproduction cohorts are intrinsically heterogeneous: cycle type, progesterone route and exposure duration, stimulation protocol, embryo ploidy/PGT status, culture media formulation, incubator conditions, and laboratory workflow can each introduce systematic variance that may be comparable to biological effects across centres and protocols, and can mask or mimic true reproductive signals [462,463,464,465]

Dosing should be individualized based on patient response and laboratory markers

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Early data showed a number of issues ranging from facial redness, nausea, and spontaneous erections

Studies in aged rats show that mitochondrial membrane potential, cardiolipin content, respiratory control ratio, and cellular oxygen uptake are significantly reduced compared to young animals, while oxidative stress markers are elevated