Yes, as with other incretin-based therapies, nausea, diarrhea, and reduced appetite are among the most commonly reported side effects, especially during dose escalation
Laboratory personnel
Theres no completed cardiovascular outcomes trial for retatrutide yet, the cause of dysesthesia isnt fully understood, and real-world data isnt available because the drug isnt approved
Those with severe laxity may see improvement but should have realistic expectations about the degree of change possible without surgery
The agency notes that its not always possible to estimate the frequency of these reactions since they are voluntarily reported
References Ali S, Ussher JR, Baggio LL, Kabir MG, Charron MJ, Ilkayeva O, Newgard CB, Drucker DJ (2014) Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction