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Some people lose muscle during GLP-1 treatment because appetite drops, total food intake decreases, and protein intake may become too low
In vitro, GLP-1(936) (30 pmol/l) alone did not increase insulin secretion when tested at either glucose concentration
The treatment group also exhibited significant increases in the expression of downstream substrate mTOR after 48 weeks and Akt after 48 and 60 weeks, but not MAPK
The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus
CONCLUSIONS Recent investigations have elucidated a multifaceted spectrum of adverse effects linked to GLP-1 RAs (Table 1), necessitating meticulous interpretation based on the various methodological designs employed, including RCTs and retrospective analyses
This makes it tough for GLP-1 receptors to work
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