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Weight Loss Plateau on Semaglutide Semaglutide (Wegovy) produces an average of 14.9% body weight loss at 68 weeks on the 2.4mg maximum dose, per the STEP 1 trial (Wilding et al., NEJM 2021)

Compounded semaglutide is a customized version of the GLP-1 (glucagon-like peptide-1) medication semaglutide, made by compounding pharmacies to suit individual needs

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The exact mechanism of the dysesthesia side effect is not known, but researchers hypothesize it may be due to the activation of the glucagon or GLP-1 receptors, as these receptors are expressed on central and peripheral nerves

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