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For instance, GLP-1s activation of signal transduction pathways not only reduces oxidative stress and apoptosis but also mitigates neuroinflammation and neurotoxicity

PARPs: Enzymes that help repair DNA damage, but use up large amounts of NAD+ in the process

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Disruption of the Ang II type 1 receptor promotes longevity in mice

The series includes the clinical development candidate PF-06882961, which we show has robust preclinical efficacy, oral bioavailability, and evidence of glucose-lowering in healthy human participants