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Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice

Since pyruvate is pivotal for entering the TCA cycle, its reduction decreases TCA flux, impairing mitochondrial energy output

M.ManentiM.LicitraG.CarpinoS

Tambin apoya la funcin heptica, un rgano vital en la metabolizacin y eliminacin de sustancias nocivas

, Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial, JAMA Cardiol