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15-HpETE-PE is catalyzed by the 15-lipoxygenase (15-LOX), which is encoded by Alox5 gene and can oxygenate polyunsaturated fatty acids to lipid peroxides (71)

First few months: This is typically the active titration phase - providers adjusting the dose based on tolerance and response, GI side effects (when present) often diminishing, and more visible weight changes becoming apparent for patients who respond to treatment

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Reconstituted Retatrutide should be used within 4 weeks