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Activation of central GLP1Rs reduces anxiety and depression behaviors in rodents 57,58 , while intravenous GLP-1 lacks anxiogenic effects in humans, even in panic disorder patients 59,60,61

Glucagon-like peptide-1 receptor agonists for weight management in mental illness: a network meta-analysis

Wegovy mimics a natural gut hormone called GLP-1

What does the clinical research say about GLP-1 medications and migraine outcomes

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4 Glucose-dependent Insulinotropic Polypeptide (GIP) GIP is produced primarily by enteroendocrine K-cells in the small intestine, specifically those within the duodenum and jejunum, and acts on specific receptors located in many of the same areas in which GLP-1 acts