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Some of the commonly used medications include: Semaglutide Tirzepatide Liraglutide Among these, tirzepatide has demonstrated the greatest average weight loss in clinical trials because it activates both GLP-1 and GIP receptors , making it more effective than GLP-1 alone

Unlike Melanotan 2, which non-selectively activates MC1R, MC3R, MC4R, and MC5R, Melanotan 1s selectivity for MC1R makes it a valuable research tool for isolating melanocortin-1 receptor biology from the broader melanocortin receptor system

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