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In addition, peripheral inflammationlinked to comorbid conditions like diabetes and HIVmay exacerbate central neuroinflammatory responses (Isik et al., 2023

In other words, participants regained two-thirds of their prior weight loss after withdrawal of SC semaglutide 2.4mg weekly

p = 0.0398)

For MC1R polymorphism studies, wild-type MC1R expressing cells as positive controls alongside variant-expressing cells are essential for quantifying functional impairment