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High levels of homocysteine can irritate arterial walls and lead to oxidative stress

Obesity-associated metabolic disease Rapidly changing lifestyle, accompanied by consumption of excess energy in the form of a calorie-rich high-fat diet, lower voluntary activity, and increased exposure to environmental pollutants, have led to an exponential rise in noncommunicable metabolic diseases [1]

These developments offer new opportunities for precision modulation and combinatorial therapies in ferroptosis-related neurodegenerative conditions

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Butyrate can reduce HFD-induced body weight gain and fat mass by enhancing energy expenditure through increased lipid oxidation in WAT (118, 120)

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