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A.ZemskyJ.PinnerE.KarpelR.PadanE.et al (1993)

The model contains only 13 zonation-dependent kinetic parameters (Supplementary Material), and metabolic zonation was simulated by manually changing enzyme activities depending on the zone that the cell belongs to, either the periportal or pericentral region

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In previous studies that compared the differentiation capacity of chondrocytes from different passages, the results indicated that cells at early passages usually generated more cartilage matrix than those at late passages upon chondroinduction ( There are several limitations in the current study