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Citrus aurantium, which contains various compounds, including synephrine alkaloids, has been suggested as a safe alternative

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- [Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)]( *JAMA*, 2021

For researchers investigating chronic low-grade inflammation (often called inflammaging), it offers a well-characterized tool compound for studying simultaneous antioxidant and anti-inflammatory responses without the systemic suppression that comes from corticosteroids or broad NSAIDs

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