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However, several conditions can increase the susceptibility to acetaminophen hepatotoxicity, such as malnutrition, chronic illness, and chronic ethanol ingestion, and the toxic dose of acetaminophen may be lower in these patients

Analyses were based on pooled data using semaglutide 0.5 mg and 1.0 mg doses for MACE and its components, hospitalization due to angina or heart failure, revascularization, and AEs

Its also why oral maintenance doses tend to be higher

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Side effects vary depending on the medication and the individual