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Tight junction proteins are the main functional proteins of the intestinal barrier, which will enlarge the intercellular space, increase intestinal mucosal permeability to increase translocation of bacteria such as Lipopolysaccharide (LPS) to cause inflammatory response (Horowitz et al., 2023)

This risk was still evident after adjusting for confounding or contributing variables

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Moreover, we tested whether cannabidiol affects the accumulation of hypoxia-inducible factor-1 alpha (HIF-1) which plays a key role in the regulation of cellular adaptation to hypoxia and oxidative stress