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Remarkably, this natural gut-brain signal improved insulin resistance and high blood sugar faster and more powerfully than the injected drug exendin-4

Acknowledgments We thank Biorender for providing fundamental materials of our scheme figures

This pentadecapeptide comprises 15 amino acids and is similar in structure to a naturally occurring peptide of the same name, mainly found in gastric juice

10.1113/jphysiol.2007.133975 104 VincentP.MulleC

The result is smoother, more radiant, and visibly healthier skin from the inside out

It appears to represent a recalibration of the brain's reward and satiety circuitry, reducing the hedonic drive to eat independently of hunger signals