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Therefore, raising cellular NAD + through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD + precursors becoming a popular supplementation approach

Funding This study was supported by Natural Science Foundation of Guangdong Province (2021A1515012393), NSFC grant (82371692, 32170825), Key laboratory of functional and clinical translational medicine, Guangdong Provincial Sports Bureau Scientific Research Project (GDSS2024N007), and Guangdong Medical Science and Technology Research Foundation (A2023145)

This may trigger an inflammatory response, contributing to symptoms

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Multi-organ distant metastases confer worse disease-specific survival in differentiated thyroid cancer