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Furthermore, -pinene activated the transient receptor potential ankyrin 1 (TRPA1) channel, amplifying its vascular effects and suggesting its potential to improve cardiovascular health through increased NO release (Jin et al., 2023)

SAG contributed to ferroptosis by increasing the Fe 2+ concentration and ROS levels and decreasing GSH levels, thus repressing the growth and metastasis of non-small cell lung cancer (NSCLC)

Within tumor cells, itaconate exerts anti-tumor effects predominantly as a result of the inhibition of the pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase, G6PDH (encoded by the G6PD gene)

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Cardiovascular Outcomes with GLP-1 Receptor Agonists