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As GLP-1RAs appear to exert their cardiovascular benefit by mechanisms different from those of both pioglitazone and SGLT2 inhibitors, there would also seem to be a place for a randomised controlled trial comparing a GLP-1RA plus pioglitazone or a GLP-1RA plus SGLT2 inhibitor compared to each monotherapy alone to establish the extent to which extra benefit is accrued with dual or even triple therapy

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In the first study, the authors did not find any significant difference in biochemical hyperandrogenism in both intra and inter-groups, despite the significant improvement in anthropometric parameters in the group treated with liraglutide [57]

It remains an investigational compound under development by Eli Lilly and Company, currently progressing through Phase 3 clinical trials

Gee regularly does low-impact cardio and strength training and gets in walks as often as he can through the workday with a treadmill desk