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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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Nitric Oxide 41, 410

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This results in the synthesis of hydrogen peroxide, which can be further metabolized by superoxide dismutase (76, 78)

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At the cellular level, proteostasis is emerging as a critical factor in the onset and progression of MetS

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