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42, 43, 44 Finally, in a prospective study in 952 postmenopausal women, an impairment in endothelial function was shown to be an efficient independent predictor of the development of arterial hypertension during a follow-up of 3.6 years

It also doesn't play nice with Avobenzone (the common UVA filter) since avobenzone destabilizes octinoxate and the two degrade each other