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Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N, Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M , Konopleva M

Rapid weight loss can disrupt oestrogen levels and the hypothalamic-pituitary-ovarian axis, potentially causing irregular periods or temporary amenorrhoea

Bioavailability refers to how much of a substance actually enters your bloodstream to be used by your body

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10.1016/j.repbio.2018.02.001 136 RatajczakM

Both flagged some examples as posing potential legal risks, under statutes that limit the claims health care providers can make about drugs that are not FDA-approved