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Conclusion Both hydroxocobalamin and vitamin B12 can be used to great effect in treating vitamin deficiency, but both can present side effects in various forms

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Malabsorption from coeliac disease, Crohns, gastric surgery or long-term metformin and proton-pump inhibitors accounts for much of the rest

However, the effect of vitamin B 12 supplementation on the risk of NTDs has not yet been evaluated in randomized controlled trials

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Essential for nerve health, DNA generation, and the creation of red blood cells, this vitamin is particularly important for older adults