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This agent has been studied in a 14-week trial and showed improvement in gouty symptoms.15 This agent may have a future role in preventing gout attacks when patients are started on a uric acid lowering agent but can take the usual prophylactic agents against the attacks that often are an early result of this therapy (for example, they can't use colchicine)

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Nausea and most gastrointestinal side effects typically resolve within 1-2 weeks as medication concentration drops, though some patients report mild digestive changes into week 3-4

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These changes build on Caremark's industry leading efforts as a pharmacy benefits manager to explore all potential avenues that help patients get FDA-approved weight management medications at an affordable cost

Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics