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By contrast, rats bearing GH-secreting tumors displayed significant glomerular hypertrophy and interstitial edema but no tubular hypertrophy, resulting in a 1.6-fold increase in kidney weight in relation to body weight compared to controls [95]

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Receptor sensitivity to dopamine could be diminished, which would explain the lack of response to increased endogenous dopamine stimulation

It is important to note that serum Se (S-Se) does not directly reflect the concentration of Se in tissues, and even normal S-Se content does not exclude the possibility of Se deficiency in the thyroid (119, 120)

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