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Genetic variants in NAT2, GST, and CYP2E1 influence metabolic rates but don't predict toxicity alone

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Key Takeaways: Rational use of medicines should always be prioritized

Future randomised controlled trials may provide clearer evidence, but clinicians and patients should be aware that the current evidence base does not support using these medications specifically to quit smoking outside of research settings

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eating too little triggers metabolic slowdown and muscle loss