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Likewise, BPC 157s therapeutic healing effects occurred to ameliorate against all adverse effects related to the crush injury as external mechanical pressure, including the counteraction of the increased enzyme activity (creatinine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase) [45]

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The above discovery implies that this activation by MSU crystals could also be TLR-independent and consistent with the effect of the relevant inflammasome