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Luckily, the math is pretty simple

Understanding the safety profile, monitoring requirements, and potential physiological interactions of these therapies is essential for anyone contemplating combined treatment

A benchmark, expand, and calibration (BenchExCal) trial emulation approach for using real-world evidence to support indication expansions: design and process for a planned empirical evaluation

Nov 2011;26(11):3537-43

Intrinsic-factor protein is produced by the cells that line the stomach