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Nature Chemical Biology
Solvent Residues : Peptides synthesized via solid-phase methods may retain trace solvents like trifluoroacetic acid (TFA)
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However, if the goal is to study systemic effectslike tendon repair, muscle recovery, or neuroprotectiona higher dose might be necessary to ensure enough of the compound survives the digestive gauntlet and reaches the bloodstream to circulate throughout the body
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