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The approved regimen begins at 2.5 mg weekly for four weeks, then increases to 5 mg weekly for four weeks, with further escalations to 7.5 mg, 10 mg, 12.5 mg, and a maximum of 15 mg weekly, each maintained for at least four weeks

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Some patients benefit from switching between tirzepatide and semaglutide formulations or exploring the PlexusDx Precision Peptide Genetic Test to describe the pathway-level variants involved