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doi: 10.1016/S0021-5198(19)43504-X 150 SadzukaYShojiTTakinoY

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337 Concurrently, age-related decreases in PINK1/Parkin-mediated mitophagy promote oxidative stress and mitochondrial dysfunction, which can trigger synovial inflammation and reduce the osteoclast activity critical for healthy bone remodeling, thereby contributing to joint damage and motor impairment

Chronic inflammation damages synaptic networks and increases excitatory signals, thus disrupting neural circuits involved in cognition, mood, and emotional regulation