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No over-the-counter, self-administered patch can safely or legally provide a controlled dose of an active peptide hormone

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Int J Epidemiol (2017) 46(3):798f

These medications can affect blood sugar levels and fat metabolism, so most clinics check a few key markers before or during treatment to track safety and progress

did not observe significant differences in amputation risk between GLP-1 receptor agonists, SGLT-2 inhibitors, and other diabetes medications in a large retrospective cohort study of 1,222,436 patients with type 2 diabetes

The difference between a good injection site and the optimal one might not show up in a single dose, but over weeks and months of consistent use, small advantages compound into meaningful outcomes