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Mechanically, ARID1A is a component of the SWI/SNF complex, which binds to the SLC7A11 promoter and promotes NRF2-mediated SLC7A11 transcriptional activation

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In intact HepG2 cells, the pan-flavoenzyme inhibitor, DPI, prevented the NFT-stimulated increase in glutathione levels, indicating the involvement of one or more of these enzymes in NFT-dependent activation of Nrf2 (Fig

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