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The mechanism by which GLP-1RAs induce reduction of body weight and hunger is believed to relate to multiple mechanisms by which GLP-1 regulates appetite and energy consumption and supports metabolic homeostasis via central neuronal pathways and through neuronal activation in the gastrointestinal tract [94, 141]

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Certain individuals, such as those with a family history of medullary thyroid cancer or severe gastrointestinal diseases, may need alternative treatments

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Peptide solutions were dried down in a refrigerated speed vac and stored at 80 C

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