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For 2 months, EE mice were housed in a huge cage (86 76 31 cm 3 ) containing novel objects, such as tunnels, shelters, toys, and running wheels for voluntary exercise, and allowing for large social interaction (1215 mice/cage) (Figure 1A) while control mice were housed in standard cages (27 22.5 14 cm 3 ) without any novel objects (45 mice/cage) (Figures 1B,C) ( ad libitum access to food and water under alternating 12-h light/dark cycles

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CNS, Central Nervous System

A subungual exostosis can be misdiagnosed or confused with other toenail abnormalities