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In a different solvent, these solvation anomalies tend to persist, thus making p K a values in the two solvents linearly proportional

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Neumann J, Hofmann B, Gergs U (2024b) Positive inotropic effects of glucose-dependent insulinotropic polypeptide in the human atrium

Shibahara et al

Although several mechanisms have recently been invoked to explain this phenomenon (including spacial and force-field factors between enzyme and substrate [Chou and Jiang, 1974], and quantum mechanical tunnelling [Garcia-Viloca et al ., 2004