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One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application

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338 Similar decreases in astrocytic expression of glutamate transports are characteristic for animal models of epilepsy, 339,340 and genetic ablation of EAAT1/2 triggers seizures

Almost all of the above cited studies have appeared in the past five years, with the majority published in the last two

Management is supportive, with a focus on fluid resuscitation and antiemetic therapy