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Those with deficiencies may need up to 1,000 mcg daily until levels normalise, then maintenance doses of 25-100 mcg

investigated the eryptosis rate in healthy RBCs treated with different concentrations of IL-6, IL-1, urea, and p -cresol, comparable to their plasma levels in CKD patients, at different time points, and evaluated the cytotoxic effect on RBCs by an in vitro setting

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During HS, the oxygen supply to cells decreases and, despite increased oxygen extraction, anaerobic metabolism sets in, leading to acidosis, coagulopathy, apoptosis, and organ dysfunction [10]

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