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doi:10.1016/j.cell.2016.02.011 7

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282 When UA levels are elevated, RAGE signaling is stimulated, leading to the activation of nuclear factor-kappa B (NF-B)

As a result, the mean anthropometric measurements of waist-to-hip ratio (WHR), waist circumference, body fat percent, and systolic blood pressure (SBP) were drastically reduced