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Recently, the hepatic differentiation of current good manufacturing practice (cGMP) compliant human iPSC (hiPSC) and hESC lines have been validated

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CYP7A1 is the rate-limiting enzyme in converting cholesterol to bile acids, and LXRs, which function as cholesterol sensors, increase Cyp7a1 expression in response to acute cholesterol intake in mice [2,33]

The dose are oral vitamin C (500 mg twice daily) and melatonin (24 mg nightly)