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Fortunately, the combination of a SGLT2i and a GLP-1RA can be used regardless of the background anti-diabetic treatment, especially metformin, since their benefits are independent of any other drugs administered simultaneously [11]

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The scientific details are covered comprehensively in the published clinical trial literature see the Selected Research References at the end of this article

Different trial designs and populations make direct comparison imperfect, but the trend is consistent (PMC12654588)

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