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Brain cells in patients with AD have been observed to exhibit biochemical and morphological features similar to ferroptosis, including GSH degradation, GPX4 inactivation, increased ROS due to iron metabolism imbalance, lipid peroxidation, and mitochondrial abnormalities

Starting a GLP-1 while in a state of untreated or poorly managed hypothyroidism can be less effective and may exacerbate certain side effects

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Semaglutide mimics GLP-1, a gut hormone that signals fullness to the brain, slows gastric emptying, and improves insulin response

doi:10.1177/1753465816677006 Jaen-Aguila F, Vargas-Hitos JA, Mediavilla-Garcia JD