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Multiple retrospective studies have shown that long-term metformin use is associated with a reduced risk of pancreatic cancer, potentially mediated by metformins activation of AMP-activated protein kinase (AMPK) and inhibition of mammalian target of rapamycin (mTOR) signaling by metformin, thereby modulating autophagy (2628)

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In vivo, a HFD reduces hepatic FGF-21 protein levels in male C57BL/6 mice, a trend that aerobic exercise can reverse to restore FGF-21 protein levels

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Use of the Gamow Bag by EMT-basic park rangers for treatment of high-altitude pulmonary edema and high-altitude cerebral edema