10.1093/jn/135.3.422 220 Rodrguez-GarcaC.Snchez-QuesadaC.ToledoE.Delgado-RodrguezM.GaforioJ
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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems
The key components of this mechanism are oxidant stress, with ferrous iron-mediated Fenton reaction and LPO as the terminal events [62]
This is because it is primarily studied for tissue remodelling and skin health rather than performance-enhancing effects like muscle growth or accelerated injury recovery