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A follow-up biomarker panel at the end of a 3 to 4-month cycle gives objective data that the protocol is moving the right numbers, which is more informative than any subjective assessment

Immunotherapy and Combination Approaches Although MPNST is generally considered an immune-cold tumor, 2025 trials are combining PD-1 blockade with MEK inhibitors or radiation therapy to enhance immune activation

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The most significant distinction is Mounjaro's dual agonist mechanism