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Optimization of glycemic control should be a target for therapy

We show that the cardioprotective actions of GLP-1(2836) do not depend on a functional transmembrane GLP-1R but rather are mediated intracellularly through type 10 soluble adenylyl cyclase (sAC), accompanied by increased cAMP levels, protein kinase A (PKA) activation, and endothelial nitric oxide synthase (eNOS) phosphorylation

The FDA approved it on April 1, 2026, for adults with obesity or adults who are overweight and have at least one weight-related health condition such as high blood pressure, high cholesterol, or type 2 diabetes

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S., Chong, P., and Rashid, P