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Because the GPX4 enzyme (which relies heavily on active glutathione to protect cell membranes) is impaired, the excess ROS molecules begin attacking the lipids that form the mitochondrial membranes

Long-term treatment must be considered in addition to short-term medicines, taking into account the potential consequences of the artificial tears, anti-inflammatory eye drops, and punctal plugs are examples of conventional treatments for dry eye disease that can be successful, but long-term use can be costly and may result in adverse effects that limit patient adherence [38, 39]

Princen HM, van Duyvenvoorde W, Buytenhek R, et al

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