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Mounjaro and Zepbound are the fastest growing

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Vasan RS, Sullivan LM, DAgostino RB, Roubenoff R, Harris T, Sawyer DB, Levy D, Wilson PW: Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study

The mechanism is not fully understood but may involve immune system activation triggered by the medication itself, changes in metabolic state during rapid weight loss, or interaction with other medications you are taking

There are several key factors that must be addressed to regulate and better coordinate the immune system

Importantly, monocytes possess the capability to stimulate ECs directly, which may lead to decreased occludin levels and a heightened influx of immune cells into the inflamed site [27]