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Customizing GLP-1 dosing plays a crucial role in balancing results and safety

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Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

Pulmonary aspiration occurred in 143 of 87,691 patients (0.16%) in the GLP-1 agonist group and 149 of 122,525 patients (0.12%) in the placebo group

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